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the first barrier building polypeptides

Created to Heal Organs, Made to Repair Skin


Sweet Chemistry is where regenerative medicine meets uncompromising cosmetic science to create evidence-based skincare worth the hype.
Elle

Voted best serum of 2023 for damaged skin

WWD

“Beauty has a new biotechnology-rooted player.”

New York Times

“Scientists revive damage lungs for transplant.”

Next

2024 Best Breakthrough Technology Finalist

Bustle

“Bone peptides might be the next retinol.”

Logo W

“Front and center in my product rotation”

PR Newswire

“Improves the structure, function, and appearance of skin.”

TZR

Winner Best Firming Serum 2024

Real Self

2023 Breakthrough Regenerative Medicine Ingredient

Clinically Proven to Increase Skin Barrier Repair, Function, and Density in 4 Weeks

Hyperpigmentation

SCARS

Inflammation

TEXTURE

Compromised Skin Barrier

Hydration

What Our Community Thinks

Every few decades, a new innovation
disrupts the skincare industry

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Repair and Regenerate Your Skin With the World’s First ECM-derived Bioactive Polypeptides

Our activity optimized formulas feature patent-pending Matrikynes® polypeptides that are naturally-derived from natural extracellular matrix and clinically-proven to: 

  • increase skin density
  • supercharge barrier function & repair 
  • increase hydration 
  • visibly reduce fine lines & deep wrinkles 
  • decrease the appearance of hyperpigmentation & age spots 

Representative VISIA CR photography. None of the above photographs were altered, edited, or retouched.

Click to Find Out What Makes Sweet Chemistry Different

Let’s Get Clinical

Independent clinical studies show that Matrikynes® deliver statistically significant improvements for multiple skin types and tones: In a clinical study of 56 women of varying race and ethnicities, Matrikynes® showed statistically significant improvements in skin barrier function, skin barrier repair, skin density, skin hydration, hyperpigmentation, and global fine lines and wrinkles.

93% saw healthier skin

"It seems to regenerate my skin."

86% saw reduced lines & wrinkles

"It improves all my fine lines and wrinkles."

91% saw improved skin looks

"Since using this, I haven't been wearing as much make-up."

91% saw improved skin texture

"My skin is smoother, brighter and firmer."

93% agree their skin looks healthier

"My skin feels healthy, hydrated and smoother"

89% saw smoother, more resilient skin

"Makes my skin look younger - the fine lines disappear."

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Bioengineering Is at the Heart, Lungs & Skin of What We Do

Aside from being our award-winning formulas’ defining ingredient, Matrikynes® are used in clinical applications in regenerative medicine: They were born from innovative research in organ tissue repair by Dr. John O’Neill, originally from Columbia University's Laboratory for Stem Cells and Tissue Engineering, and his team at our parent company Xylyx Bio.

Beyond creating this novel peptide technology we use in our products exclusively, Xylyx Bio develops biomaterials and organ support systems: From lifesaving surgical lung sealants, to advanced platform technologies for organ rehabilitation and transplantation, to helping discover novel cancer and fibrosis treatments.  

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8 Years of Research & Over $8 Million In NIH Government Funding

Originally used in clinical applications to repair lung tissue, Matrikynes® are a proprietary combination of potent bioactive natural matrikine signal peptides. Matrikine signal peptides have been shown to improve the structure, function, and appearance of skin.

• Increased Cellular Renewal By 336%
• Reduced Wound Size By 421%
• Increased Regenerative Gene Expression By 316%

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The Origins of Matrikynes®

These matrikine signal peptides are derived from extracellular matrix (ECM), the essential, life-sustaining substance that surrounds every cell in your body. Without extracellular matrix, life could not exist.

ECM gives cells the ability to organize and communicate which signals your skin to regenerate and repair.

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Finding Healing in the Extracellular Matrix

Skin tissue is made up of water, cells, and an essential substance called extracellular matrix (ECM).  The ECM is made up of structural proteins you might be familiar with such as collagen, elastin, laminin, and fibronectin, and contain components such as hyaluronic acid, ceramides, squalene, glycosaminoglycans, cholesterol, minerals, epidermal growth factors, and many other substances that are essential to the human body.

Skin ECM supports cell function and helps cells communicate, repair, and regenerate, which is essential for maintaining a healthy skin barrier. Over time, due to factors like sun exposure, stress, and aging, skin ECM starts to break down, resulting in a progressive loss of important ECM components like collagen, which eventually leads to the development of fine lines and wrinkles. 

While traditional formulas use synthetic/artificial peptides to help rebuild collagen with some success, we also formulate with our proprietary, highly bioavailable ECM polypeptides, which are derived from ethically-sourced, USDA-compliant, upcycled bovine bones the food industry would otherwise discard. 

What makes bone the source of choice for our polypeptides is that it is a tissue with natural regenerative properties and an unparalleled reparative capacity.

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Unlocking Unparalleled
Skin Health

To create Sweet Chemistry Matrikynes®, our scientists break down extracellular matrix proteins into skin penetrable peptide fragments using a process known as proteolysis. 

As one of the defining actives in our products, these proprietary Matrikynes® polypeptides act as a signal that tells your skin to produce more collagen which helps increase skin density, and thereby reduce the appearance of fine lines/wrinkles. Matrikynes® also help maintain and improve overall skin texture, and firmness, as well as target redness, hyperpigmentation, and skin barrier concerns.

Rather than a marketing "complex", our technology ingredient has been assessed and granted its own internationally recognized INCI name and is patent-pending. This allows us to be the only brand to harness this technology in the world.

“Without ECM, Life Could Not Exist.
Plants Would Not Grow Tall, and Animals
Could neither Swim, nor Walk, nor Fly.”

 - WH LEWIS, LIFE SCIENCES AND CELL BIOLOGY, 1922

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The Beauty of Belonging

Having healthy beautiful skin is a wonderful thing, but we believe our industry, the beauty industry, has work to do in how we present the concept of beauty as a whole. It lies in the unique abilities, skills, and experiences that shape not only the way you look and feel but how you engage with people and shape who you are holistically. 

As a beauty brand, it is our responsibility to try help heal the rigid understanding of beauty by fostering a community where people, especially the youth, can feel empowered to express and explore themselves in ways that go beyond looks. 

That is why, beyond selling skincare products, we donate 1% of our sales to programs that nurture the next generation of young scientists and artists who are looking to create a more beautiful future. And because beauty goes beyond skin deep, we use our brand as a platform to bring awareness to our parent company Xylyx Bio's groundbreaking research in organ rehabilitation.

free returns

free shipping

Conscientious sourcing

reduced environmental impact

Cruelty free