Lung Rehabilitation Using Xenogeneic Cross-Circulation Does Not Lead to Hyperacute Rejection in a Human Lung Transplantation Model

Lung Rehabilitation Using Xenogeneic Cross-Circulation Does Not Lead to Hyperacute Rejection in a Human Lung Transplantation Model

Access to life-saving lung transplantation remains limited by a shortage of donor organs. We have previously described rehabilitation of discarded human donor lungs to a quality suitable for transplantation using cross-circulation of whole blood between xeno-support swine and human lungs. However, the immunologic implications of transplanting rehabilitated lungs remain unknown.