The extracellular matrix (ECM) is a complex mixture surrounding live cells, composed of fibrous proteins that provide structure and physical support, and other types of molecules that function in signaling and cell health.

Despite increasing use of machine perfusion as an organ preservation and rescue technique in liver transplantation, significant organ shortages and waitlist mortality highlight a continuing need for improved organ recovery methods. 

Manifestations of cystic fibrosis, although well-characterized in the proximal airways, are understudied in the distal lung. Characterization of the cystic fibrosis lung 'matrisome' (matrix proteome) has not been previously described, and could help identify biomarkers...

Researchers at the University of Illinois applied Xylyx Bio's IN SITE™ Metastasis Kit to evaluate a cancer therapeutic.

Xenogeneic cross-circulation is a promising method to recover marginal lungs. It may be more advantageous than EVLP but could introduce risks of zoonotic infections and sensitization to xenoantigens.

Advanced EVLP with xenogeneic support could complement machine perfusion modalities such as isolated EVLP to expand donor organ recovery and increase the number of lungs available for transplantation.

Although machine perfusion has gained momentum as an organ preservation technique in liver transplantation, persistent organ shortages and high waitlist mortality highlight unmet needs for improved organ salvage strategies.

Xenogeneic cross-circulation is a promising method to recover marginal lungs. It may be more advantageous than EVLP but could introduce risks of zoonotic infections and sensitization to xenoantigens.

Award supports development of a pre-clinical compound testing platform to predict anti-fibrotic drug response