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Pathological Remodeling of Distal Lung Matrix in End-Stage Cystic Fibrosis Patients

Pathological Remodeling of Distal Lung Matrix in End-Stage Cystic Fibrosis Patients

Manifestations of cystic fibrosis, although well-characterized in the proximal airways, are understudied in the distal lung. Characterization of the cystic fibrosis lung 'matrisome' (matrix proteome) has not been previously described, and could help identify biomarkers...
Xylyx Bio Collaboration Reveals New Insights into Tumor Drug Resistance

Xylyx Bio Collaboration Reveals New Insights into Tumor Drug Resistance

Researchers at the University of Illinois applied Xylyx Bio's IN SITE™ Metastasis Kit to evaluate a cancer therapeutic.
Commentary: The Ultimate Ex Vivo Lung Perfusion: Xenogeneic Cross-Circulation

Commentary: The Ultimate Ex Vivo Lung Perfusion: Xenogeneic Cross-Circulation

Xenogeneic cross-circulation is a promising method to recover marginal lungs. It may be more advantageous than EVLP but could introduce risks of zoonotic infections and sensitization to xenoantigens.
Xenogeneic Support for the Recovery of Human Donor Organs

Xenogeneic Support for the Recovery of Human Donor Organs

Advanced EVLP with xenogeneic support could complement machine perfusion modalities such as isolated EVLP to expand donor organ recovery and increase the number of lungs available for transplantation.
Cross-Circulation for Extracorporeal Liver Support in a Swine Model

Cross-Circulation for Extracorporeal Liver Support in a Swine Model

Although machine perfusion has gained momentum as an organ preservation technique in liver transplantation, persistent organ shortages and high waitlist mortality highlight unmet needs for improved organ salvage strategies.
Xylyx Bio Awarded $2.2M NIH SBIR Fast-Track Grant from National Heart, Lung, and Blood Institute

Xylyx Bio Awarded $2.2M NIH SBIR Fast-Track Grant from National Heart, Lung, and Blood Institute

Award supports development of a pre-clinical compound testing platform to predict anti-fibrotic drug response
In Astounding Test, Scientists Revive Damaged Lungs for Transplant

In Astounding Test, Scientists Revive Damaged Lungs for Transplant

Injured and unusable lungs were restored with respirators and pig blood.  The procedure one day may increase the supply of organs for transplant.
Xenogeneic Cross-Circulation for Extracorporeal Recovery of Injured Human Lungs

Xenogeneic Cross-Circulation for Extracorporeal Recovery of Injured Human Lungs

Here we demonstrate that acutely injured human lungs declined for transplantation, including a lung that failed to recover on EVLP, can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire...
Multiday Maintenance of Extracorporeal Lungs Using Cross-Circulation With Conscious Swine

Multiday Maintenance of Extracorporeal Lungs Using Cross-Circulation With Conscious Swine

Lung remains the least-utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex vivo perfusion systems are limited to <24 hours of support. Here, we demonstrate the feasibility of extending normothermic extracorporeal...