INCI: Sodium Acetylated Hyaluronate - Also known as: Acetylated Hyaluronic Acid Sodium Salt, Lipophilic HA, Long-Lasting HA

QUICK FACTS

What is Sodium Acetylated Hyaluronate?

Sodium Acetylated Hyaluronate is a chemically modified form of hyaluronic acid in which hydroxyl groups on the hyaluronate backbone have been partially substituted with acetyl groups through esterification. This acetylation changes hyaluronic acid's molecular character in a specific and functionally meaningful way: the acetyl groups increase the molecule's affinity for the skin's own cell surface and intercellular lipid environment, giving sodium acetylated hyaluronate a notably stronger and longer-lasting skin-surface residency than unmodified sodium hyaluronate at equivalent concentrations.

In comparative studies, sodium acetylated hyaluronate has been shown to remain associated with the skin's surface for significantly longer periods after application than standard high-molecular-weight HA - with some research suggesting its surface residency may extend several hours beyond that of conventional HA. This prolonged contact with the skin surface is studied in connection with a more sustained hydration contribution throughout the day, rather than the more immediate but shorter-duration effect associated with standard HA.

At Sweet Chemistry, sodium acetylated hyaluronate is the fourth and final member of the four-form HA complex used across all three water-based formulas - completing a system that delivers four distinct HA types (standard sodium hyaluronate, crosspolymer, hydrolyzed, and acetylated) to address different depths and durations of skin hydration simultaneously.

What does it do for skin?

Sodium acetylated hyaluronate's primary contribution is sustained surface moisture retention. Its increased affinity for the skin's cell surface and lipid environment means it is associated with forming a more persistent moisture-retaining film than standard HA - delivering a longer-duration hydration contribution that may reduce the rate of moisture evaporation from the skin's surface throughout the day, even as the initial hydrating effect of the other HA forms is absorbed.

Research on acetylated hyaluronate has explored its skin-surface interaction in connection with a more plump, smooth, and comfortable-feeling skin surface over an extended wear period - a studied distinction from the immediate but more transient hydration plumping associated with low-molecular-weight hydrolyzed HA at the same time point. In the context of the Sweet Chemistry four-form HA approach, sodium acetylated hyaluronate provides the sustained duration dimension alongside the surface film of standard HA, the deeper epidermal penetration of hydrolyzed HA, and the enhanced surface adhesion of the crosspolymer form.

FOUND IN

In 3 Formulas as Part of the Four-Form HA Complex

Sodium Acetylated Hyaluronate is present in all three Sweet Chemistry water-based formulas as the long-residency member of the four-form hyaluronic acid system - contributing sustained surface hydration duration to complement the other HA forms' different depths and mechanisms.

Nourishment - All Skin Types

Barrier Repairing Hydra-Serum Sodium Acetylated Hyaluronate (with 3 other HA forms) - 1.0 oz / 30 ml

The Hydra-Serum delivers all four HA forms within a 40%-active emulsion alongside glycerin, PCA, sodium PCA, sodium lactate, and eleven amino acids - the most complete NMF and HA hydration system in the Sweet Chemistry lineup.

Hydration - Dry to Normal

Elasticity Reinforcing Hydra-Cream Sodium Acetylated Hyaluronate (with 3 other HA forms) - 1.7 oz / 50 ml

The Hydra-Cream delivers the four-form HA system alongside 3% Matrikynes® peptides and 2% THD ascorbate in a 40%-active cushioned satin finish for dry to normal skin.

Hydration - Dry to Dehydrated

Elasticity Reinforcing Lipid-Cream Sodium Acetylated Hyaluronate (with 3 other HA forms) - 1.7 oz / 50 ml

In the Lipid-Cream, the four-form HA complex provides multi-depth and multi-duration hydration within the most emollient formula in the lineup - surface hydration and structural emollience working together.

WORKS TOGETHER WITH

Standard HA Sodium Hyaluronate

INCI: Sodium Hyaluronate.

The standard high-molecular-weight HA form in all three water-based formulas, associated with surface film-forming hydration. Synergy Note: Standard sodium hyaluronate provides an immediate surface hydration contribution; sodium acetylated hyaluronate is studied in connection with extending that hydration contribution over time through superior skin-surface residency. Immediate and sustained hydration from the same molecular family.

Crosslinked HA Sodium Hyaluronate Crosspolymer

INCI: Sodium Hyaluronate Crosspolymer.

A cross-linked HA form in all three water-based formulas with enhanced surface film-forming character. Synergy Note: The crosspolymer's cross-linked architecture increases surface adhesion relative to standard HA; sodium acetylated hyaluronate's acetyl modification increases cell-surface affinity. Together they address surface residency from two distinct polymer modification strategies.

Penetrating HA Hydrolyzed Sodium Hyaluronate

INCI: Hydrolyzed Sodium Hyaluronate.

A low-molecular-weight HA form in all three water-based formulas, associated with deeper epidermal penetration. Synergy Note: Hydrolyzed HA addresses moisture binding at greater epidermal depth; sodium acetylated hyaluronate addresses sustained surface moisture retention - together they create a complementary depth-and-duration hydration approach within the four-form system.

ECM Peptide Complex Matrikynes® Bone Peptides

INCI: Hydrolyzed Cow Bone Extract.

At 3% in all four formulas. Synergy Note: Hyaluronic acid is a component of the same extracellular matrix environment that Matrikynes® targets - sodium acetylated hyaluronate's sustained surface hydration contribution supports the surface moisture environment in which dermal-targeting peptide activity takes place.