Advanced EVLP with xenogeneic support could complement machine perfusion modalities such as isolated EVLP to expand donor organ recovery and increase the number of lungs available for transplantation.

Although machine perfusion has gained momentum as an organ preservation technique in liver transplantation, persistent organ shortages and high waitlist mortality highlight unmet needs for improved organ salvage strategies.

Xenogeneic cross-circulation is a promising method to recover marginal lungs. It may be more advantageous than EVLP but could introduce risks of zoonotic infections and sensitization to xenoantigens.

Award supports development of a pre-clinical compound testing platform to predict anti-fibrotic drug response

With 3D cell culture making strong inroads into preclinical studies and basic research, the focus of vendors and investigators alike has turned from discovery to optimization.

IN MATRICO™ compound testing services accurately predict in-vivo drug response

Advances in cell culture techniques don’t just mean more accurate models, but more personal ones. 

Normal and fibrotic NativeCoat™ ECM substrates increase predictiveness of high throughput compound screening

Advance could increase the number of suitable organs for transplant